Losmapimod

DB12270InvestigationalSmall molecule

Losmapimod has been investigated for the prevention of Chronic Obstructive Pulmonary Disease.

Mechanism: Pharmacologically active on Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11
Curator reviewed
Formula / weight: C₂₂H₂₆FN₃O₂ · 383.467 g/mol (avg)
Code names: GW856553 · GW-856553X

Resolves to

Compound

Structure

InChIKeyKKYABQBFGDZVNQ-UHFFFAOYSA-NSMILESCC1=C(C=C(C=C1F)C(=O)NC1CC1)C1=CC=C(C=N1)C(=O)NCC(C)(C)C

Targets

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

19Clinical trialsPhase, status and sponsor resolved per trial

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Losmapimod, and which of those have an active Phase 3 trial?

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