Baculoviral IAP repeat-containing protein 5

BE0003408ProteinHumansBIRC5

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). It is acted on by 8 drugs in DrugBank.

Gene name
BIRC5
UniProtKB entry
O15392Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
142 residues · 16,389 Da
Also known as
API4 · Apoptosis inhibitor 4 · Apoptosis inhibitor survivin · IAP4

Resolves to

Protein
UniProtO15392UniProt nameBIRC5_HUMAN
Gene
HGNCHGNC:593NCBI Gene332GeneCardsBIRC5
Pharmacology
IUPHAR/GtoPdb2795KEGGhsa:332
Structure
PDB1E31PDB1F3HPDB1XOX
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
23Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
24GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
47+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Baculoviral IAP repeat-containing protein 5, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In