Berberine

DB04115ApprovedInvestigationalWithdrawnSmall molecule

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal...

Chemical structure of Berberine
Mechanism
Curator reviewed
Formula / weight
C20H18NO4 · 336.3612 g/mol (avg)

Resolves to

Compound
UNII0I8Y3P32UFCAS2086-83-1ChEMBLCHEMBL295124ChEBI16118PubChem2353KEGGD00092
Clinical / RWD
RxNorm1437PharmGKBPA165860812
Structure
InChIKeyYBHILYKTIRIUTE-UHFFFAOYSA-NSMILESCOC1=CC=C2C=C3C4=CC5=C(OCO5)C=C4CC[N+]3=CC2=C1OC
Targets
Q9Y478PRKAB1P22303ACHEP15121AKR1B1P27487DPP4O08398ftsZQ96EB6SIRT1Q8NBP7PCSK9Q12809KCNH2+3 more
Transporters
P08183ABCB1Q9UNQ0ABCG2O15244SLC22A2O15245SLC22A1Q96FL8SLC47A1

What you can answer from here — as of September 23, 2026

12Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
5TransportersSubstrate / inhibitor direction, not just membership
Listed above
57Clinical trialsPhase, status and sponsor resolved per trial
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1Marketed productAcross 1 country and 1 labeller
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24+ReferencesStructured and connected to the statements they support
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