Integrin beta-7

BE0003414ProteinHumansITGB7

Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). It is acted on by 6 drugs in DrugBank.

Gene name
ITGB7
UniProtKB entry
P26010Swiss-Prot
Cellular location
Cell membrane
Residues / weight
798 residues · 86,902 Da
Also known as
Gut homing receptor beta subunit

Resolves to

Protein
UniProtP26010UniProt nameITB7_HUMAN
Gene
HGNCHGNC:6162NCBI Gene3695GeneCardsITGB7
Pharmacology
IUPHAR/GtoPdb2461KEGGhsa:3695
Structure
PDB2BRQPDB3V4PPDB3V4V
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin beta-7, how selective are they, and which programs against it are still in active trials?

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