cAMP-dependent protein kinase type I-alpha regulatory subunit

BE0003425ProteinHumansPRKAR1A

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. It is acted on by 4 drugs in DrugBank.

Gene name
PRKAR1A
UniProtKB entry
P10644Swiss-Prot
Cellular location
Cell membrane
Residues / weight
381 residues · 42,981 Da
Also known as
PKR1 · PRKAR1 · Tissue-specific extinguisher 1 · TSE1

Resolves to

Protein
UniProtP10644UniProt nameKAP0_HUMAN
Gene
HGNCHGNC:9388NCBI Gene5573GeneCardsPRKAR1A
Pharmacology
IUPHAR/GtoPdb1472KEGGhsa:5573
Structure
PDB5KJXPDB5KJYPDB5KJZ
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which compounds in development act on cAMP-dependent protein kinase type I-alpha regulatory subunit, and which indications are they being tested in?

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