High mobility group protein B1

BE0003428ProteinHumansHMGB1

Multifunctional redox sensitive protein with various roles in different cellular compartments. It is acted on by 7 drugs in DrugBank.

Gene name
HMGB1
UniProtKB entry
P09429Swiss-Prot
Cellular location
Nucleus
Residues / weight
215 residues · 24,894 Da
Also known as
High mobility group protein 1 · HMG-1 · HMG1

Resolves to

Protein
UniProtP09429UniProt nameHMGB1_HUMAN
Gene
HGNCHGNC:4983NCBI Gene3146GeneCardsHMGB1
Pharmacology
IUPHAR/GtoPdb3279KEGGhsa:3146
Structure
PDB2LY4PDB2RTUPDB2YRQ
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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64GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on High mobility group protein B1, how selective are they, and which programs against it are still in active trials?

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