Mitogen-activated protein kinase kinase kinase 1

BE0003430ProteinHumansMAP3K1

Component of a protein kinase signal transduction cascade (PubMed:9808624). It is acted on by 5 drugs in DrugBank.

Gene name
MAP3K1
UniProtKB entry
Q13233Swiss-Prot
Residues / weight
1,512 residues · 164,468 Da
Also known as
2.7.11.25 · MAPK/ERK kinase kinase 1 · MAPKKK1 · MEK kinase 1 · MEKK

Resolves to

Protein
UniProtQ13233UniProt nameM3K1_HUMAN
Gene
HGNCHGNC:6848NCBI Gene4214GeneCardsMAP3K1
Pharmacology
IUPHAR/GtoPdb2069KEGGhsa:4214
Structure
PDB6WHB
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
22Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
21+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Mitogen-activated protein kinase kinase kinase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In