U-0126

DB17060ExperimentalSmall molecule

U-0126 is a direct inhibitor of the mitogen-activated protein-kinase kinase family members, MEK-1 and MEK-2.

Chemical structure of U-0126
Formula / weight
C18H16N6S2 · 380.49 g/mol (avg)
Also known as
1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene · Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-, (2z,3z)-
Code names
EDV-2209 · FT-1069-1 · U-0126

Resolves to

Compound
UNII8027P94HLLCAS218601-62-8ChEMBLCHEMBL34704ChEBI90693
Structure
InChIKeyDVEXZJFMOKTQEZ-JYFOCSDGSA-NSMILESN\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=C(N)C=CC=C1
Targets
Q13233MAP3K1Q9Y2U5MAP3K2

What you can answer from here — as of July 17, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
3+ReferencesStructured and connected to the statements they support
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