Growth/differentiation factor 8

BE0003435ProteinHumansMSTN

Acts specifically as a negative regulator of skeletal muscle growth. It is acted on by 11 drugs in DrugBank.

Gene name
MSTN
UniProtKB entry
O14793Swiss-Prot
Cellular location
Secreted
Residues / weight
375 residues · 42,750 Da
Also known as
GDF-8 · GDF8 · Myostatin

Resolves to

Protein
UniProtO14793UniProt nameGDF8_HUMAN
Gene
HGNCHGNC:4223NCBI Gene2660GeneCardsMSTN
Pharmacology
KEGGhsa:2660
Structure
PDB5F3BPDB5F3HPDB5NTU
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Growth/differentiation factor 8, how selective are they, and which programs against it are still in active trials?

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