Complement C3

BE0003455ProteinHumansC3

Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune... It is acted on by 14 drugs in DrugBank.

Gene name
C3
UniProtKB entry
P01024Swiss-Prot
Cellular location
Secreted
Residues / weight
1,663 residues · 187,147 Da
Also known as
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 · CPAMD1

Resolves to

Protein
UniProtP01024UniProt nameCO3_HUMAN
Gene
HGNCHGNC:1318NCBI Gene718GeneCardsC3
Pharmacology
KEGGhsa:718
Structure
PDB1C3DPDB1GHQPDB1W2S
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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12Pfam domainsDomain architecture mapped to Pfam families and clans
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82+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement C3, how selective are they, and which programs against it are still in active trials?

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