Microtubule-associated protein 4

Details

Name
Microtubule-associated protein 4
Kind
protein
Synonyms
  • MAP-4
Gene Name
MAP4
UniProtKB Entry
P27816Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037238|Microtubule-associated protein 4
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS
ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP
EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP
CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE
IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM
ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI
KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ
ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ
LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM
EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG
ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE
LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ
PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK
APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE
GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST
TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT
EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG
GNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL
PAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA
QTLDSQIQETSI
Number of residues
1152
Molecular Weight
121003.805
Theoretical pI
5.07
GO Classification
Functions
microtubule stabilizing activity / RNA binding
Processes
cilium disassembly / microtubule cytoskeleton organization / microtubule polymerization / negative regulation of non-motile cilium assembly
Components
axon / axoneme / cytosol / microtubule organizing center
General Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly
Specific Function
microtubule binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, cytoskeleton
Gene sequence
>lcl|BSEQ0012426|Microtubule-associated protein 4 (MAP4)
ATGGCTGACCTCAGTCTTGCAGATGCATTAACAGAACCATCTCCAGACATTGAGGGAGAG
ATAAAGCGGGACTTCATTGCCACACTAGAGGCAGAGGCCTTTGATGATGTTGTGGGAGAA
ACTGTTGGAAAAACAGACTATATTCCTCTCCTGGATGTTGATGAGAAAACCGGGAACTCA
GAGTCAAAGAAGAAACCGTGCTCAGAAACTAGCCAGATTGAAGATACTCCATCTTCTAAA
CCAACACTCCTAGCCAATGGTGGTCATGGAGTAGAAGGGAGCGATACTACAGGGTCTCCA
ACTGAATTCCTTGAAGAGAAAATGGCCTACCAGGAATACCCAAATAGCCAGAACTGGCCA
GAAGATACCAACTTTTGTTTCCAACCTGAGCAAGTGGTCGATCCTATCCAGACTGATCCC
TTTAAGATGTACCATGATGATGACCTGGCAGATTTGGTCTTTCCCTCCAGTGCGACAGCT
GATACTTCAATATTTGCAGGACAAAATGATCCCTTGAAAGACAGTTACGGTATGTCTCCC
TGCAACACAGCTGTTGTACCTCAGGGGTGGTCTGTGGAAGCCTTAAACTCTCCACACTCA
GAGTCCTTTGTTTCCCCAGAGGCTGTTGCAGAACCTCCTCAGCCAACGGCAGTTCCCTTA
GAGCTAGCCAAGGAGATAGAAATGGCATCAGAAGAGAGGCCACCAGCACAAGCATTGGAA
ATAATGATGGGACTGAAGACTACTGACATGGCACCATCTAAAGAAACAGAGATGGCCCTC
GCCAAGGACATGGCACTAGCTACAAAAACCGAGGTGGCATTGGCTAAAGATATGGAATCA
CCCACCAAATTAGATGTGACACTGGCCAAGGACATGCAGCCATCCATGGAATCAGATATG
GCCCTAGTCAAGGACATGGAACTACCCACAGAAAAAGAAGTGGCCCTGGTTAAGGATGTC
AGATGGCCCACAGAAACAGATGTATCTTCAGCCAAGAATGTGGTACTGCCCACAGAAACA
GAGGTAGCCCCAGCCAAGGATGTGACACTGTTGAAAGAAACAGAGAGGGCATCTCCTATA
AAAATGGACTTAGCCCCTTCCAAGGACATGGGACCACCCAAAGAAAACAAGAAAGAAACA
GAGAGGGCATCTCCTATAAAAATGGACTTGGCTCCTTCCAAGGACATGGGACCACCCAAA
GAAAACAAGATAGTCCCAGCCAAGGATTTGGTATTACTCTCAGAAATAGAGGTGGCACAG
GCTAATGACATTATATCATCCACAGAAATATCCTCTGCTGAGAAGGTGGCTTTGTCCTCA
GAAACAGAGGTAGCCCTGGCCAGGGACATGACACTGCCCCCGGAAACCAACGTGATCTTG
ACCAAGGATAAAGCACTACCTTTAGAAGCAGAGGTGGCCCCAGTCAAGGACATGGCTCAA
CTCCCAGAAACAGAAATAGCCCCGGCCAAGGATGTGGCTCCGTCCACAGTAAAAGAAGTG
GGCTTGTTGAAGGACATGTCTCCACTATCAGAAACAGAAATGGCTCTGGGCAAGGATGTG
ACTCCACCTCCAGAAACAGAAGTAGTTCTCATCAAGAACGTATGTCTGCCTCCAGAAATG
GAGGTGGCCCTGACTGAGGATCAGGTCCCAGCCCTCAAAACAGAAGCACCCCTGGCTAAG
GATGGGGTTCTGACCCTGGCCAACAATGTGACTCCAGCCAAAGATGTTCCACCACTCTCA
GAAACAGAGGCAACACCAGTTCCAATTAAAGACATGGAAATTGCACAAACACAAAAAGGA
ATAAGTGAGGATTCCCATTTAGAATCTCTGCAGGATGTGGGGCAGTCAGCTGCACCTACT
TTCATGATTTCACCAGAAACCGTCACAGGAACGGGGAAAAAGTGCAGCTTGCCGGCCGAG
GAGGATTCTGTGTTAGAAAAACTAGGGGAAAGGAAACCATGCAACAGTCAACCTTCTGAG
CTTTCTTCAGAGACCTCAGGAATAGCCAGGCCAGAAGAAGGAAGGCCTGTGGTGAGTGGG
ACAGGAAATGACATCACCACCCCACCGAACAAGGAGCTCCCACCAAGCCCAGAGAAGAAA
ACAAAGCCTTTGGCCACCACTCAACCTGCAAAGACTTCAACATCGAAAGCCAAAACACAG
CCCACTTCTCTCCCTAAGCAGCCAGCTCCCACCACCATTGGTGGGTTGAATAAAAAACCC
ATGAGCCTTGCTTCAGGCTTAGTGCCAGCTGCCCCACCCAAACGCCCTGCCGTCGCCTCT
GCCAGGCCTTCCATCTTACCTTCAAAAGACGTGAAGCCAAAGCCCATTGCAGATGCAAAG
GCTCCTGAGAAGCGGGCCTCACCATCCAAGCCAGCTTCTGCCCCAGCCTCCAGATCTGGG
TCCAAGAGCACTCAGACTGTTGCAAAAACCACAACAGCTGCTGCTGTTGCCTCAACTGGC
CCAAGCAGTAGGAGCCCCTCCACGCTCCTGCCCAAGAAGCCCACTGCCATTAAGACTGAG
GGAAAACCTGCAGAAGTCAAGAAGATGACTGCAAAGTCTGTACCAGCTGACTTGAGTCGC
CCAAAGAGCACCTCCACCAGTTCCATGAAGAAAACCACCACTCTCAGTGGGACAGCCCCC
GCTGCAGGGGTGGTTCCCAGCCGAGTCAAGGCCACACCCATGCCCTCCCGGCCCTCCACA
ACTCCTTTCATAGACAAGAAGCCCACCTCGGCCAAACCCAGCTCCACCACCCCCCGGCTC
AGCCGCCTGGCCACCAATACTTCTGCTCCTGATCTGAAGAATGTCCGCTCCAAGGTTGGC
TCCACGGAAAACATCAAGCATCAGCCTGGAGGAGGCCGGGCCAAAGTAGAGAAAAAAACA
GAGGCAGCTGCTACAACCCGAAAGCCTGAATCTAATGCAGTCACTAAAACAGCCGGCCCA
ATTGCAAGTGCACAGAAACAACCTGCGGGGAAAGTCCAGATAGTCTCCAAAAAAGTGAGC
TACAGCCATATTCAGTCCAAGTGTGGTTCCAAGGACAATATTAAGCATGTCCCTGGAGGT
GGTAATGTTCAGATTCAGAACAAGAAAGTGGACATCTCTAAGGTCTCCTCCAAGTGTGGG
TCTAAGGCTAACATCAAGCACAAGCCTGGTGGAGGAGATGTCAAGATTGAAAGTCAGAAG
TTGAACTTCAAGGAGAAGGCCCAGGCCAAGGTGGGATCCCTCGATAATGTGGGCCACCTA
CCTGCAGGAGGTGCTGTGAAGATTGAGACCTACAGGCTGACGTTCCGGGCAAATGCCAGG
GCCCGCACCGACCACGGGGCCGACATTGTCTCCCGCCCCCCACACTTCCCTGGCGGCCCC
AACTCGGGCTCCCGGGTCCTTGGCCCCCTTTCCCGGGCTGTCCACTAG
Chromosome Location
3
Locus
3p21.31
External Identifiers
ResourceLink
UniProtKB IDP27816
UniProtKB Entry NameMAP4_HUMAN
GenBank Gene IDBC015149
GeneCard IDMAP4
GenAtlas IDMAP4
HGNC IDHGNC:6862
KEGG IDhsa:4134
NCBI Gene ID4134
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Paclitaxelapproved, vet_approvedyestargetDetails
Docetaxelapproved, investigationalyestargetDetails
Artenimolapproved, experimental, investigationalunknowntargetligandDetails