Melanin-concentrating hormone receptor 1

BE0003478ProteinHumansMCHR1

G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (PubMed:10421367, PubMed:15340116, PubMed:38710677, PubMed:39616153). It is acted on by 3 drugs in DrugBank.

Gene name
MCHR1
UniProtKB entry
Q99705Swiss-Prot
Cellular location
Cell membrane
Residues / weight
353 residues · 38,939 Da
Also known as
G protein-coupled receptor 24 · GPR24 · MCH receptor 1 · MCH-1R · MCH-R1

Resolves to

Protein
UniProtQ99705UniProt nameMCHR1_HUMAN
Gene
HGNCHGNC:4479NCBI Gene2847GeneCardsMCHR1
Pharmacology
IUPHAR/GtoPdb280KEGGhsa:2847
Structure
PDB8WSSPDB8WWHPDB8WWI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Melanin-concentrating hormone receptor 1, how selective are they, and which programs against it are still in active trials?

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