Melanin-concentrating hormone receptor 1
Details
- Name
- Melanin-concentrating hormone receptor 1
- Kind
- protein
- Synonyms
- G-protein coupled receptor 24
- GPR24
- MCH receptor 1
- MCH-1R
- MCH-R1
- MCH1R
- MCHR
- MCHR-1
- SLC-1
- SLC1
- Somatostatin receptor-like protein
- Gene Name
- MCHR1
- UniProtKB Entry
- Q99705Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0061834|Melanin-concentrating hormone receptor 1 MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNST VIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT AMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWL YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVA PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
- Number of residues
- 353
- Molecular Weight
- 38939.29
- Theoretical pI
- 9.13
- GO Classification
- FunctionsG protein-coupled receptor activity / hormone binding / neuropeptide binding / signaling receptor bindingProcessesadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway / neuropeptide signaling pathway / positive regulation of calcium ion transportComponentscilium / neuron projection / non-motile cilium
- General Function
- Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis
- Specific Function
- G protein-coupled receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 45-67 80-102 117-139 159-181 210-232 253-275 290-312
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012427|Melanin-concentrating hormone receptor 1 (MCHR1) ATGTCAGTGGGAGCCATGAAGAAGGGAGTGGGGAGGGCAGTTGGGCTTGGAGGCGGCAGC GGCTGCCAGGCTACGGAGGAAGACCCCCTTCCCAACTGCGGGGCTTGCGCTCCGGGACAA GGTGGCAGGCGCTGGAGGCTGCCGCAGCCTGCGTGGGTGGAGGGGAGCTCAGCTCGGTTG TGGGAGCAGGCGACCGGCACTGGCTGGATGGACCTGGAAGCCTCGCTGCTGCCCACTGGT CCCAACGCCAGCAACACCTCTGATGGCCCCGATAACCTCACTTCGGCAGGATCACCTCCT CGCACGGGGAGCATCTCCTACATCAACATCATCATGCCTTCGGTGTTCGGCACCATCTGC CTCCTGGGCATCATCGGGAACTCCACGGTCATCTTCGCGGTCGTGAAGAAGTCCAAGCTG CACTGGTGCAACAACGTCCCCGACATCTTCATCATCAACCTCTCGGTAGTAGATCTCCTC TTTCTCCTGGGCATGCCCTTCATGATCCACCAGCTCATGGGCAATGGGGTGTGGCACTTT GGGGAGACCATGTGCACCCTCATCACGGCCATGGATGCCAATAGTCAGTTCACCAGCACC TACATCCTGACCGCCATGGCCATTGACCGCTACCTGGCCACTGTCCACCCCATCTCTTCC ACGAAGTTCCGGAAGCCCTCTGTGGCCACCCTGGTGATCTGCCTCCTGTGGGCCCTCTCC TTCATCAGCATCACCCCTGTGTGGCTGTATGCCAGACTCATCCCCTTCCCAGGAGGTGCA GTGGGCTGCGGCATACGCCTGCCCAACCCAGACACTGACCTCTACTGGTTCACCCTGTAC CAGTTTTTCCTGGCCTTTGCCCTGCCTTTTGTGGTCATCACAGCCGCATACGTGAGGATC CTGCAGCGCATGACGTCCTCAGTGGCCCCCGCCTCCCAGCGCAGCATCCGGCTGCGGACA AAGAGGGTGACCCGCACAGCCATCGCCATCTGTCTGGTCTTCTTTGTGTGCTGGGCACCC TACTATGTGCTACAGCTGACCCAGTTGTCCATCAGCCGCCCGACCCTCACCTTTGTCTAC TTATACAATGCGGCCATCAGCTTGGGCTATGCCAACAGCTGCCTCAACCCCTTTGTGTAC ATCGTGCTCTGTGAGACGTTCCGCAAACGCTTGGTCCTGTCGGTGAAGCCTGCAGCCCAG GGGCAGCTTCGCGCTGTCAGCAACGCTCAGACGGCTGACGAGGAGAGGACAGAAAGCAAA GGCACCTGA
- Chromosome Location
- 22
- Locus
- 22q13.2
- External Identifiers
Resource Link UniProtKB ID Q99705 UniProtKB Entry Name MCHR1_HUMAN GenBank Gene ID U71092 GeneCard ID MCHR1 GenAtlas ID MCHR1 HGNC ID HGNC:4479 PDB ID(s) 8WSS KEGG ID hsa:2847 IUPHAR/Guide To Pharmacology ID 280 NCBI Gene ID 2847 - General References
- Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, Fujino M: Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. Biochem Biophys Res Commun. 1999 Aug 11;261(3):622-6. [Article]
- Wermter AK, Reichwald K, Buch T, Geller F, Platzer C, Huse K, Hess C, Remschmidt H, Gudermann T, Preibisch G, Siegfried W, Goldschmidt HP, Li WD, Price RA, Biebermann H, Krude H, Vollmert C, Wichmann HE, Illig T, Sorensen TI, Astrup A, Larsen LH, Pedersen O, Eberle D, Clement K, Blundell J, Wabitsch M, Schafer H, Platzer M, Hinney A, Hebebrand J: Mutation analysis of the MCHR1 gene in human obesity. Eur J Endocrinol. 2005 Jun;152(6):851-62. [Article]
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
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- Kolakowski LF Jr, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF: Characterization of a human gene related to genes encoding somatostatin receptors. FEBS Lett. 1996 Dec 2;398(2-3):253-8. [Article]
- Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, Park J, Ellis C, Ganguly S, Konchar S, Cluderay J, Leslie R, Wilson S, Sarau HM: Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 1999 Jul 15;400(6741):261-5. [Article]
- Francke F, Ward RJ, Jenkins L, Kellett E, Richter D, Milligan G, Bachner D: Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization. J Biol Chem. 2006 Oct 27;281(43):32496-507. Epub 2006 Aug 31. [Article]
- Gibson WT, Pissios P, Trombly DJ, Luan J, Keogh J, Wareham NJ, Maratos-Flier E, O'Rahilly S, Farooqi IS: Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. Obes Res. 2004 May;12(5):743-9. [Article]
- Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS: Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. Obes Res. 2004 Aug;12(8):1327-34. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details NGD-4715 investigational yes target antagonist Details Haloperidol approved unknown target Details BMS-830216 investigational yes target antagonist Details