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NGD-4715

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Identification

Generic Name
NGD-4715
DrugBank Accession Number
DB06027
Background

NGD-4715 is an investigational compound developed for the treatment of Obesity. NGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 422.323
Monoisotopic: 421.100105
Chemical Formula
C19H24BrN3O3
Synonyms
  • 1-(5-bromo-6-methoxypyridin-2-yl)-4-(3,4-dimethoxybenzyl)piperazine
  • 1-(5-bromo-6-methoxypyridin-2-yl)-4-[(3,4-dimethoxyphenyl)methyl]piperazine
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Pharmacology

Indication

Investigated for use/treatment in obesity.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action

NGD-4715 works as a small molecule antagonist at the melanin concentrating hormone receptor-1 (MCHR1). Neurogen’s obesity program has focused on blocking the melanin concentrating hormone receptor-1 (MCH1). Reported studies in rodents support MCH being an important mediator of caloric intake. Deletion of MCH or the MCH1 receptor gene resulted in lean animals, while over-production of MCH caused increased weight gain. Neurogen’s studies indicated that selectively blocking MCH1 was sufficient to achieve a significant reduction in food intake in a higher animal species.

TargetActionsOrganism
AMelanin-concentrating hormone receptor 1
antagonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
476322-70-0
InChI Key
VAKYVNYLCIABRV-UHFFFAOYSA-N
InChI
InChI=1S/C19H24BrN3O3/c1-24-16-6-4-14(12-17(16)25-2)13-22-8-10-23(11-9-22)18-7-5-15(20)19(21-18)26-3/h4-7,12H,8-11,13H2,1-3H3
IUPAC Name
SMILES
COC1=C(OC)C=C(CN2CCN(CC2)C2=NC(OC)=C(Br)C=C2)C=C1

References

General References
Not Available
ChemSpider
8042584
Wikipedia
NGD-4715

Clinical Trials

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Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Melanin-concentrating hormone receptor 1
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Antagonist
General Function
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis
Specific Function
G protein-coupled receptor activity
Gene Name
MCHR1
Uniprot ID
Q99705
Uniprot Name
Melanin-concentrating hormone receptor 1
Molecular Weight
38939.29 Da
References
  1. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]

Drug created at November 18, 2007 18:29 / Updated at August 26, 2024 19:22