Transforming growth factor beta-2 proprotein

BE0003481ProteinHumansTGFB2

Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. It is acted on by 7 drugs in DrugBank.

Gene name
TGFB2
UniProtKB entry
P61812Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
414 residues · 47,747 Da
Also known as
Cetermin · G-TSF · Glioblastoma-derived T-cell suppressor factor

Resolves to

Protein
UniProtP61812UniProt nameTGFB2_HUMAN
Gene
HGNCHGNC:11768NCBI Gene7042GeneCardsTGFB2
Pharmacology
KEGGhsa:7042
Structure
PDB1TFGPDB2TGIPDB4KXZ
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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63GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Transforming growth factor beta-2 proprotein, and which indications are they being tested in?

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