T-cell surface glycoprotein CD4

BE0003488ProteinHumansCD4

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. It is acted on by 10 drugs in DrugBank.

Gene name
CD4
UniProtKB entry
P01730Swiss-Prot
Cellular location
Cell membrane
Residues / weight
458 residues · 51,110 Da
Also known as
T-cell surface antigen T4/Leu-3

Resolves to

Protein
UniProtP01730UniProt nameCD4_HUMAN
Gene
HGNCHGNC:1678NCBI Gene920GeneCardsCD4
Pharmacology
KEGGhsa:920
Structure
PDB1CDHPDB1CDIPDB1CDJ
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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438Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell surface glycoprotein CD4, how selective are they, and which programs against it are still in active trials?

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