B-lymphocyte antigen CD19

BE0003496ProteinHumansCD19

Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). It is acted on by 36 drugs in DrugBank.

Gene name
CD19
UniProtKB entry
P15391Swiss-Prot
Cellular location
Cell membrane
Residues / weight
556 residues · 61,128 Da
Also known as
B-lymphocyte surface antigen B4 · Differentiation antigen CD19 · T-cell surface antigen Leu-12

Resolves to

Protein
UniProtP15391UniProt nameCD19_HUMAN
Gene
HGNCHGNC:1633NCBI Gene930GeneCardsCD19
Pharmacology
IUPHAR/GtoPdb2764KEGGhsa:930
Structure
PDB6AL5PDB7JICPDB7URV
Drugs

What you can answer from here — as of September 07, 2019

36DrugsApproved to experimental, with action, bond type and pharmacological action
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117Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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127+ReferencesStructured and connected to the statements they support
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Which approved drugs act on B-lymphocyte antigen CD19, how selective are they, and which programs against it are still in active trials?

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