Carboxypeptidase N catalytic chain

BE0003503ProteinHumansCPN1

Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. It is acted on by 5 drugs in DrugBank.

Gene name
CPN1
UniProtKB entry
P15169Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
458 residues · 52,286 Da
Also known as
3.4.17.3 · ACBP · Anaphylatoxin inactivator · Arginine carboxypeptidase · Carboxypeptidase N polypeptide 1

Resolves to

Protein
UniProtP15169UniProt nameCBPN_HUMAN
Gene
HGNCHGNC:2312NCBI Gene1369GeneCardsCPN1
Pharmacology
IUPHAR/GtoPdb1597KEGGhsa:1369
Structure
PDB2NSM
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carboxypeptidase N catalytic chain, how selective are they, and which programs against it are still in active trials?

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