ORE-1001

DB12271InvestigationalSmall molecule

ORE1001 has been used in trials studying the treatment of Mild to Moderate Ulcerative Colitis. It is an ACE2 inhibitor.

Chemical structure of ORE-1001
Formula / weight
C19H23Cl2N3O4 · 428.31 g/mol (avg)
Code names
GL-1001 · MLN-4760 · ORE-1001 · ORE-1001 FREE ACID

Resolves to

Compound
UNII4LD0ZHV25KCAS305335-31-3ChEMBLCHEMBL429844PubChem448281
Structure
InChIKeyNTCCRGGIJNDEAB-IRXDYDNUSA-NSMILESCC(C)C[C@H](N[C@@H](CC1=CN=CN1CC1=CC(Cl)=CC(Cl)=C1)C(O)=O)C(O)=O
Targets
Q9BYF1ACE2P15169CPN1P22792CPN2

What you can answer from here — as of January 29, 2025

3Protein targetsEach mapped to UniProt, with action and pharmacological action
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1Clinical trialPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with ORE-1001, and which of those have an active Phase 3 trial?

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