Interleukin-4

BE0003520ProteinHumansIL4

Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727). It is acted on by 5 drugs in DrugBank.

Gene name
IL4
UniProtKB entry
P05112Swiss-Prot
Cellular location
Secreted
Residues / weight
153 residues · 17,492 Da
Also known as
B-cell stimulatory factor 1 · Binetrakin · BSF-1 · IL-4 · Lymphocyte stimulatory factor 1

Resolves to

Protein
UniProtP05112UniProt nameIL4_HUMAN
Gene
HGNCHGNC:6014NCBI Gene3565GeneCardsIL4
Pharmacology
KEGGhsa:3565
Structure
PDB1BBNPDB1BCNPDB1CYL
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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23Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-4, how selective are they, and which programs against it are still in active trials?

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