Motilin receptor

Details

Name
Motilin receptor
Kind
protein
Synonyms
  • G-protein coupled receptor 38
  • GPR38
  • MTLR
  • MTLR1
Gene Name
MLNR
UniProtKB Entry
O43193Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006793|Motilin receptor
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTV
MLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEG
CTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVE
QDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPA
QLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVL
LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISK
KYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
Number of residues
412
Molecular Weight
45343.725
Theoretical pI
10.17
GO Classification
Functions
G protein-coupled peptide receptor activity / hormone binding
Processes
G protein-coupled receptor signaling pathway
Components
cytosol
General Function
Receptor for motilin
Specific Function
G protein-coupled peptide receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
36-56 75-94 113-134 158-178 247-270 299-320 335-358
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012452|Motilin receptor (MLNR)
ATGGGCAGCCCCTGGAACGGCAGCGACGGCCCCGAGGGGGCGCGGGAGCCGCCGTGGCCC
GCGCTGCCGCCTTGCGACGAGCGCCGCTGCTCGCCCTTTCCCCTGGGGGCGCTGGTGCCG
GTGACCGCTGTGTGCCTGTGCCTGTTCGTCGTCGGGGTGAGCGGCAACGTGGTGACCGTG
ATGCTGATCGGGCGCTACCGGGACATGCGGACCACCACCAACTTGTACCTGGGCAGCATG
GCCGTGTCCGACCTACTCATCCTGCTCGGGCTGCCGTTCGACCTGTACCGCCTCTGGCGC
TCGCGGCCCTGGGTGTTCGGGCCGCTGCTCTGCCGCCTGTCCCTCTACGTGGGCGAGGGC
TGCACCTACGCCACGCTGCTGCACATGACCGCGCTCAGCGTCGAGCGCTACCTGGCCATC
TGCCGCCCGCTCCGCGCCCGCGTCTTGGTCACCCGGCGCCGCGTCCGCGCGCTCATCGCT
GTGCTCTGGGCCGTGGCGCTGCTCTCTGCCGGTCCCTTCTTGTTCCTGGTGGGCGTCGAG
CAGGACCCCGGCATCTCCGTAGTCCCGGGCCTCAATGGCACCGCGCGGATCGCCTCCTCG
CCTCTCGCCTCGTCGCCGCCTCTCTGGCTCTCGCGGGCGCCACCGCCGTCCCCGCCGTCG
GGGCCCGAGACCGCGGAGGCCGCGGCGCTGTTCAGCCGCGAATGCCGGCCGAGCCCCGCG
CAGCTGGGCGCGCTGCGTGTCATGCTGTGGGTCACCACCGCCTACTTCTTCCTGCCCTTT
CTGTGCCTCAGCATCCTCTACGGGCTCATCGGGCGGGAGCTGTGGAGCAGCCGGCGGCCG
CTGCGAGGCCCGGCCGCCTCGGGGCGGGAGAGAGGCCACCGGCAGACCGTCCGCGTCCTG
CTGGTGGTGGTTCTGGCATTTATAATTTGCTGGTTGCCCTTCCACGTTGGCAGAATCATT
TACATAAACACGGAAGATTCGCGGATGATGTACTTCTCTCAGTACTTTAACATCGTCGCT
CTGCAACTTTTCTATCTGAGCGCATCTATCAACCCAATCCTCTACAACCTCATTTCAAAG
AAGTACAGAGCGGCGGCCTTTAAACTGCTGCTCGCAAGGAAGTCCAGGCCGAGAGGCTTC
CACAGAAGCAGGGACACTGCGGGGGAAGTTGCAGGGGACACTGGAGGAGACACGGTGGGC
TACACCGAGACAAGCGCTAACGTGAAGACGATGGGATAA
Chromosome Location
13
Locus
13q14.2
External Identifiers
ResourceLink
UniProtKB IDO43193
UniProtKB Entry NameMTLR_HUMAN
GenBank Gene IDAL137000
GeneCard IDMLNR
GenAtlas IDMLNR
HGNC IDHGNC:4495
PDB ID(s)8IBU, 8IBV
KEGG IDhsa:2862
IUPHAR/Guide To Pharmacology ID297
NCBI Gene ID2862
General References
  1. McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH: Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. Genomics. 1997 Dec 15;46(3):426-34. [Article]
  2. Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD: Receptor for motilin identified in the human gastrointestinal system. Science. 1999 Jun 25;284(5423):2184-8. [Article]
  3. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
  4. Smith RG, Leonard R, Bailey AR, Palyha O, Feighner S, Tan C, Mckee KK, Pong SS, Griffin P, Howard A: Growth hormone secretagogue receptor family members and ligands. Endocrine. 2001 Feb;14(1):9-14. [Article]

Associated Data

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