Tryptophan 2,3-dioxygenase

BE0003532ProteinHumansTDO2

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. It is acted on by 4 drugs in DrugBank.

Gene name
TDO2
UniProtKB entry
P48775Swiss-Prot
Residues / weight
406 residues · 47,871 Da
Also known as
1.13.11.11 · TDO · TO · TRPO · Tryptamin 2,3-dioxygenase

Resolves to

Protein
UniProtP48775UniProt nameT23O_HUMAN
Gene
HGNCHGNC:11708NCBI Gene6999GenBank993046GeneCardsTDO2
Pharmacology
IUPHAR/GtoPdb2887KEGGhsa:6999
Structure
PDB4PW8PDB5TI9PDB5TIA
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan 2,3-dioxygenase, how selective are they, and which programs against it are still in active trials?

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