Tolmetin is an NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
- Mechanism
- Curator reviewed
The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action. Tolmetin does not appear to alter the course of the underlying disease in man.
- Primary indication
- For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management.Curator reviewed · 6 structured indications
- Formula / weight
- C15H15NO3 · 257.2845 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1991
- Code names
- MCN-2559 · McN 2559-21-98
- Brand names
Resolves to
UPSPUYADGBWSHF-UHFFFAOYSA-NSMILESCN1C(CC(O)=O)=CC=C1C(=O)C1=CC=C(C)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Tolmetin, and which of those have an active Phase 3 trial?
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