6-phosphogluconate dehydrogenase, decarboxylating

BE0003559ProteinHumansPGD

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. It is acted on by 12 drugs in DrugBank.

Gene name
PGD
UniProtKB entry
P52209Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
483 residues · 53,140 Da
Also known as
1.1.1.44 · PGDH

Resolves to

Protein
UniProtP52209UniProt name6PGD_HUMAN
Gene
HGNCHGNC:8891NCBI Gene5226GenBank984325GeneCardsPGD
Pharmacology
KEGGhsa:5226
Structure
PDB2JKVPDB4GWGPDB4GWK
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 6-phosphogluconate dehydrogenase, decarboxylating, how selective are they, and which programs against it are still in active trials?

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