Homidium

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Homidium
DrugBank Accession Number
DB17031
Background

Homidium is a group II compound with trypanocidal effects.1

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 314.411
Monoisotopic: 314.165174076
Chemical Formula
C21H20N3
Synonyms
  • 2,7-diamino-10-ethyl-9-phenylphenanthridinium
  • 2,7-diamino-9-phenyl-10-ethylphenanthridinium
  • 3,8-diamino-5-ethyl-6-phenylphenanthridinium
  • Babidium
  • Ethidium
  • Homidium cation
  • Homidium ion
  • Novidium
External IDs
  • RD-1572

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Homidium bromide059NUO2Z1L1239-45-8Not applicable

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
EN464416SI
CAS number
3546-21-2
InChI Key
QTANTQQOYSUMLC-UHFFFAOYSA-O
InChI
InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1
IUPAC Name
3,8-diamino-5-ethyl-6-phenylphenanthridin-5-ium
SMILES
CC[N+]1=C(C2=CC=CC=C2)C2=C(C=CC(N)=C2)C2=C1C=C(N)C=C2

References

General References
  1. HAWKING F, SEN AB: The trypanocidal action of homidium, quinapyramine and suramin. Br J Pharmacol Chemother. 1960 Dec;15:567-70. doi: 10.1111/j.1476-5381.1960.tb00283.x. [Article]
ChemSpider
3498
BindingDB
50105463
ChEBI
42478
ChEMBL
CHEMBL48166
ZINC
ZINC000000119632
PDBe Ligand
ET
Wikipedia
Ethidium_bromide
PDB Entries
1jty / 1oy9 / 1qvu / 1t9x / 2zoz / 3br3 / 3htj / 3pm1 / 3q2y / 3v78
show 11 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility8.01e-06 mg/mLALOGPS
logP0.83ALOGPS
logP-0.91Chemaxon
logS-7.6ALOGPS
pKa (Strongest Basic)3.63Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area55.92 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity102 m3·mol-1Chemaxon
Polarizability36.33 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 17:16 / Updated at December 13, 2022 10:46