This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Homidium
- DrugBank Accession Number
- DB17031
- Background
Homidium is a group II compound with trypanocidal effects.1
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Homidium (DB17031)
- Weight
- Average: 314.411
Monoisotopic: 314.165174076 - Chemical Formula
- C21H20N3
- Synonyms
- 2,7-diamino-10-ethyl-9-phenylphenanthridinium
- 2,7-diamino-9-phenyl-10-ethylphenanthridinium
- 3,8-diamino-5-ethyl-6-phenylphenanthridinium
- Babidium
- Ethidium
- Homidium cation
- Homidium ion
- Novidium
- External IDs
- RD-1572
Pharmacology
- Indication
Not Available
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Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Homidium bromide 059NUO2Z1L 1239-45-8 Not applicable
Categories
- Drug Categories
- Anti-Infective Agents
- Anticholinergic Agents
- Antiparasitic Agents
- Antiprotozoals
- Cholinergic Agents
- Coloring Agents
- Compounds used in a research, industrial, or household setting
- Enzyme Inhibitors
- Fluorescent Dyes
- Heterocyclic Compounds, Fused-Ring
- Indicators and Reagents
- Laboratory Chemicals
- Luminescent Agents
- Neurotransmitter Agents
- Nicotinic Antagonists
- Phenanthridines
- Trypanocidal Agents
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- EN464416SI
- CAS number
- 3546-21-2
- InChI Key
- QTANTQQOYSUMLC-UHFFFAOYSA-O
- InChI
- InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1
- IUPAC Name
- 3,8-diamino-5-ethyl-6-phenylphenanthridin-5-ium
- SMILES
- CC[N+]1=C(C2=CC=CC=C2)C2=C(C=CC(N)=C2)C2=C1C=C(N)C=C2
References
- General References
- HAWKING F, SEN AB: The trypanocidal action of homidium, quinapyramine and suramin. Br J Pharmacol Chemother. 1960 Dec;15:567-70. doi: 10.1111/j.1476-5381.1960.tb00283.x. [Article]
- External Links
- ChemSpider
- 3498
- BindingDB
- 50105463
- ChEBI
- 42478
- ChEMBL
- CHEMBL48166
- ZINC
- ZINC000000119632
- PDBe Ligand
- ET
- Wikipedia
- Ethidium_bromide
- PDB Entries
- 1jty / 1oy9 / 1qvu / 1t9x / 2zoz / 3br3 / 3htj / 3pm1 / 3q2y / 3v78 … show 11 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 8.01e-06 mg/mL ALOGPS logP 0.83 ALOGPS logP -0.91 Chemaxon logS -7.6 ALOGPS pKa (Strongest Basic) 3.63 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 55.92 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 102 m3·mol-1 Chemaxon Polarizability 36.33 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at October 11, 2022 17:16 / Updated at December 13, 2022 10:46