Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.

Mechanism of action

Ritodrine is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions.

Target	Actions	Organism
ABeta-2 adrenergic receptor	agonist	Humans
ABeta adrenergic receptor	agonist downregulator	Humans
AATP-sensitive potassium channel	activator	Humans
UCalcium transporting ATPases	inhibitor	Humans
ACalcium-activated potassium channel	activator	Humans
UMyosin light chain kinase, smooth muscle	inhibitor	Humans
USulfotransferase 1C4	substrate	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

~56%

Metabolism

Hepatic, by both the mother and fetus

Route of elimination

Not Available

Half-life

1.7-2.6 hours

Clearance

Not Available

Adverse Effects

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Toxicity

LD₅₀=64mg/kg (mice, IV); LD₅₀=540 mg/kg (mice, oral); LD₅₀=85 mg/kg (rat, IV)

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acebutolol	The therapeutic efficacy of Ritodrine can be decreased when used in combination with Acebutolol.
Aceclofenac	The risk or severity of hypertension can be increased when Ritodrine is combined with Aceclofenac.
Acemetacin	The risk or severity of hypertension can be increased when Ritodrine is combined with Acemetacin.
Acetylsalicylic acid	The risk or severity of hypertension can be increased when Ritodrine is combined with Acetylsalicylic acid.
Aclidinium	The risk or severity of Tachycardia can be increased when Ritodrine is combined with Aclidinium.
Adenosine	The risk or severity of Tachycardia can be increased when Adenosine is combined with Ritodrine.
Alclofenac	The risk or severity of hypertension can be increased when Ritodrine is combined with Alclofenac.
Alfentanil	The risk or severity of hypertension can be increased when Alfentanil is combined with Ritodrine.
Alfuzosin	The therapeutic efficacy of Ritodrine can be decreased when used in combination with Alfuzosin.
Aliskiren	Ritodrine may decrease the antihypertensive activities of Aliskiren.

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Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Ritodrine hydrochloride	ESJ56Q60GC	23239-51-2	IDLSITKDRVDKRV-JSUROZADSA-N

International/Other Brands

Yutopar

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Yutopar Inj 50mg/5ml	Liquid	10 mg / mL	Intravenous	Bristol Labs Division Of Bristol Myers Squibb	1984-12-31	2001-07-30
Yutopar Tab 10mg	Tablet	10 mg / tab	Oral	Bristol Labs Division Of Bristol Myers Squibb	1984-12-31	2001-07-30

Chemical Identifiers

UNII: I0Q6O6740J
CAS number: 26652-09-5
InChI Key: IOVGROKTTNBUGK-SJKOYZFVSA-N
InChI: InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m1/s1
IUPAC Name: 4-[(1S,2R)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
SMILES: C[C@@H](NCCC1=CC=C(O)C=C1)[C@@H](O)C1=CC=C(O)C=C1

References

Synthesis Reference

Naoki Yamazaki, Yoshimasa Fukuda, Yoshiaki Shibazaki, Tetsutarou Niizato, Isao Kosugi, Shin Yoshioka, "(-)-ritodrine, therapeutic compositions and use, and method of preparation." U.S. Patent US5449694, issued July, 1992.

US5449694

General References

Not Available

External Links

Human Metabolome Database: HMDB0015005
KEGG Drug: D02359
KEGG Compound: C07239
PubChem Compound: 33572
PubChem Substance: 46505273
ChemSpider: 599993
BindingDB: 50493311
RxNav: 9392
ChEBI: 156577
ChEMBL: CHEMBL489553
ZINC: ZINC000000057483
Therapeutic Targets Database: DAP000937
PharmGKB: PA451258
Drugs.com: Drugs.com Drug Page
Wikipedia: Ritodrine

MSDS

Download (48 KB)

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Premature Births	1
4	Unknown Status	Prevention	Preterm Labor Without Delivery	1
1	Completed	Treatment	Healthy Subjects (HS)	1
Not Available	Completed	Treatment	Pregnancy	1
Not Available	Completed	Treatment	Premature Labour	1

Pharmacoeconomics

Manufacturers

Abraxis pharmaceutical products
Hospira inc
Astrazeneca lp

Packagers

Solvay Pharmaceuticals

Dosage Forms

Form	Route	Strength
Injection, solution	Intramuscular; Parenteral	10 MG/2ML
Injection, solution	Parenteral	50 MG/5ML
Tablet	Oral	10 MG
Injection	Intramuscular; Intravenous	50 mg/5ml
Liquid	Intravenous	10 mg / mL
Tablet	Oral	10 mg / tab

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	88-90 °C	Not Available
water solubility	Complete	Not Available
logP	2.4	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.179 mg/mL	ALOGPS
logP	1.53	ALOGPS
logP	1.82	Chemaxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	9.15	Chemaxon
pKa (Strongest Basic)	9.81	Chemaxon
Physiological Charge	1	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	4	Chemaxon
Polar Surface Area	72.72 Å²	Chemaxon
Rotatable Bond Count	6	Chemaxon
Refractivity	83.02 m³·mol^-1	Chemaxon
Polarizability	31.9 Å³	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.9871
Blood Brain Barrier	-	0.8115
Caco-2 permeable	-	0.5546
P-glycoprotein substrate	Substrate	0.692
P-glycoprotein inhibitor I	Non-inhibitor	0.953
P-glycoprotein inhibitor II	Non-inhibitor	0.8732
Renal organic cation transporter	Non-inhibitor	0.6134
CYP450 2C9 substrate	Non-substrate	0.6367
CYP450 2D6 substrate	Substrate	0.5054
CYP450 3A4 substrate	Non-substrate	0.5874
CYP450 1A2 substrate	Non-inhibitor	0.9045
CYP450 2C9 inhibitor	Non-inhibitor	0.9442
CYP450 2D6 inhibitor	Non-inhibitor	0.6034
CYP450 2C19 inhibitor	Non-inhibitor	0.9025
CYP450 3A4 inhibitor	Non-inhibitor	0.8351
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.7277
Ames test	Non AMES toxic	0.7799
Carcinogenicity	Non-carcinogens	0.9177
Biodegradation	Not ready biodegradable	0.8862
Rat acute toxicity	2.2303 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.7534
hERG inhibition (predictor II)	Inhibitor	0.5409

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Targets

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Details1. Beta-2 adrenergic receptor

Kind: Protein
Organism: Humans
Pharmacological action: Yes
Actions: Agonist

General Function: Protein homodimerization activity
Specific Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately ...
Gene Name: ADRB2
Uniprot ID: P07550
Uniprot Name: Beta-2 adrenergic receptor
Molecular Weight: 46458.32 Da

References

Tanaka N, Tamai T, Mukaiyama H, Hirabayashi A, Muranaka H, Akahane S, Miyata H, Akahane M: Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence. J Med Chem. 2001 Apr 26;44(9):1436-45. [Article]
Schwarz MK, Page P: Preterm labour: an overview of current and emerging therapeutics. Curr Med Chem. 2003 Aug;10(15):1441-68. [Article]
Lye SJ, Dayes BA, Freitag CL, Brooks J, Casper RF: Failure of ritodrine to prevent preterm labor in the sheep. Am J Obstet Gynecol. 1992 Nov;167(5):1399-408. [Article]
Bianchetti A, Manara L: In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon. Br J Pharmacol. 1990 Aug;100(4):831-9. [Article]
Lenselink DR, Kuhlmann RS, Lawrence JM, Kolesari GL: Cardiovascular teratogenicity of terbutaline and ritodrine in the chick embryo. Am J Obstet Gynecol. 1994 Aug;171(2):501-6. [Article]
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]
Basilisco G, Camboni MG, Bozzani A, Molgora M, Bianchi PA: Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome. Br J Clin Pharmacol. 1990 Mar;29(3):355-8. doi: 10.1111/j.1365-2125.1990.tb03647.x. [Article]
Leveno KJ, Little BB, Cunningham FG: The national impact of ritodrine hydrochloride for inhibition of preterm labor. Obstet Gynecol. 1990 Jul;76(1):12-5. [Article]
Fabry IG, De Paepe P, Kips JG, Van Bortel LM: The influence of tocolytic drugs on cardiac function, large arteries, and resistance vessels. Eur J Clin Pharmacol. 2011 Jun;67(6):573-80. doi: 10.1007/s00228-011-1040-5. Epub 2011 Apr 15. [Article]
Shimokawa S, Sakata A, Suga Y, Isoda K, Itai S, Nagase K, Shimada T, Sai Y: Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study. J Pharm Health Care Sci. 2019 Apr 16;5:7. doi: 10.1186/s40780-019-0137-3. eCollection 2019. [Article]
Brashear WT, Kuhnert BR, Wei R: Structural determination of the conjugated metabolites of ritodrine. Drug Metab Dispos. 1990 Jul-Aug;18(4):488-93. [Article]
Fabry I, De Paepe P, Kips J, Vermeersch S, Van Bortel L: Different effects of tocolytic medication on blood pressure and blood pressure amplification. Eur J Clin Pharmacol. 2011 Jan;67(1):11-7. doi: 10.1007/s00228-010-0926-y. Epub 2010 Nov 16. [Article]
Dennedy MC, Friel AM, Gardeil F, Morrison JJ: Beta-3 versus beta-2 adrenergic agonists and preterm labour: in vitro uterine relaxation effects. BJOG. 2001 Jun;108(6):605-9. doi: 10.1111/j.1471-0528.2001.00147.x. [Article]
Brashear WT, Kuhnert BR, Wei R: Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates. Clin Pharmacol Ther. 1988 Dec;44(6):634-41. doi: 10.1038/clpt.1988.205. [Article]
Pacifici GM, Quilici MC, Giulianetti B, Spisni R, Nervi M, Giuliani L, Gomeni R: Ritodrine sulphation in the human liver and duodenal mucosa: interindividual variability. Eur J Drug Metab Pharmacokinet. 1998 Jan-Mar;23(1):67-74. doi: 10.1007/BF03189829. [Article]
Sato Y, Teraki Y, Izaki S, Baba K: Ritodrine-induced erythematous papular eruption in 14 pregnant women. Int J Dermatol. 2010 Dec;49(12):1450-3. doi: 10.1111/j.1365-4632.2010.04633.x. [Article]
Wu CD, Chao AS, Cheng PJ, Soong YK: Ritodrine-induced leukopenia: a case report and literature review. Changgeng Yi Xue Za Zhi. 1996 Dec;19(4):388-91. [Article]
Mangrella M, Torella M, Russo F, Rossi F, Piucci B, Cantoni V: [Pharmacology of ritodrine]. Minerva Ginecol. 1999 Jun;51(6):233-44. [Article]
Chae J, Cho GJ, Oh MJ, Park K, Han SW, Choi SJ, Oh SY, Roh CR: In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age. Sci Rep. 2021 Jan 13;11(1):1146. doi: 10.1038/s41598-020-80904-y. [Article]
Pacifici GM, Kubrich M, Giuliani L, de Vries M, Rane A: Sulphation and glucuronidation of ritodrine in human foetal and adult tissues. Eur J Clin Pharmacol. 1993;44(3):259-64. doi: 10.1007/BF00271368. [Article]

Details2. Beta adrenergic receptor (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: Yes
Actions: Agonist
Downregulator

General Function: Receptor signaling protein activity
Specific Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately e...

Components:

Name	UniProt ID
Beta-1 adrenergic receptor	P08588
Beta-2 adrenergic receptor	P07550
Beta-3 adrenergic receptor	P13945

References

Anumba DO, Ford GA, Boys RJ, Robson SC: Stimulated nitric oxide release and nitric oxide sensitivity in forearm arterial vasculature during normotensive and preeclamptic pregnancy. Am J Obstet Gynecol. 1999 Dec;181(6):1479-84. doi: 10.1016/s0002-9378(99)70394-7. [Article]
Hamada Y, Nakaya Y, Hamada S, Kamada M, Aono T: Activation of K+ channels by ritodrine hydrochloride in uterine smooth muscle cells from pregnant women. Eur J Pharmacol. 1994 Dec 15;288(1):45-51. doi: 10.1016/0922-4106(94)90008-6. [Article]
de Heus R, Mulder EJ, Derks JB, Visser GH: Acute tocolysis for uterine activity reduction in term labor: a review. Obstet Gynecol Surv. 2008 Jun;63(6):383-8; quiz 405. doi: 10.1097/OGX.0b013e31816ff75b. [Article]
Caritis SN, Lin LS, Wong LK: Evaluation of the pharmacodynamics and pharmacokinetics of ritodrine when administered as a loading dose. On establishing a potentially useful drug administration regimen in cases of fetal distress. Am J Obstet Gynecol. 1985 Aug 15;152(8):1026-31. [Article]
Ekblad U, Grenman S, Kaila T: The effect of a short-term ritodrine treatment on the concentration of beta-adrenergic receptors in human myometrium. Ann Chir Gynaecol Suppl. 1987;202:29-31. [Article]
Pedzinska-Betiuk A, Modzelewska B, Jozwik M, Jozwik M, Kostrzewska A: Differences in the effects of beta2- and beta3-adrenoceptor agonists on spontaneous contractions of human nonpregnant myometrium. Ginekol Pol. 2011 Dec;82(12):918-24. [Article]
Plenge-Tellechea F, Soler F, Fernandez-Belda F: Ritodrine inhibition of the plasma membrane Ca2+-ATPase from human erythrocyte. Arch Biochem Biophys. 1998 Sep 15;357(2):179-84. doi: 10.1006/abbi.1998.0812. [Article]

Details3. ATP-sensitive potassium channel (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: Yes
Actions: Activator

General Function: Phosphatidylinositol-4,5-bisphosphate binding
Specific Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than...

Components:

Name	UniProt ID
ATP-sensitive inward rectifier potassium channel 1	P48048
ATP-sensitive inward rectifier potassium channel 10	P78508
ATP-sensitive inward rectifier potassium channel 11	Q14654
ATP-sensitive inward rectifier potassium channel 12	Q14500
ATP-sensitive inward rectifier potassium channel 14	Q9UNX9
ATP-sensitive inward rectifier potassium channel 15	Q99712
ATP-sensitive inward rectifier potassium channel 8	Q15842

References

Hamada Y, Nakaya Y, Hamada S, Kamada M, Aono T: Activation of K+ channels by ritodrine hydrochloride in uterine smooth muscle cells from pregnant women. Eur J Pharmacol. 1994 Dec 15;288(1):45-51. doi: 10.1016/0922-4106(94)90008-6. [Article]

Details4. Calcium transporting ATPases (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Signal transducer activity
Specific Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.

Components:

Name	UniProt ID
Calcium-transporting ATPase type 2C member 1	P98194
Calcium-transporting ATPase type 2C member 2	O75185
Plasma membrane calcium-transporting ATPase 1	P20020
Plasma membrane calcium-transporting ATPase 2	Q01814
Plasma membrane calcium-transporting ATPase 3	Q16720
Plasma membrane calcium-transporting ATPase 4	P23634
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	O14983
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P16615

References

Plenge-Tellechea F, Soler F, Fernandez-Belda F: Ritodrine inhibition of the plasma membrane Ca2+-ATPase from human erythrocyte. Arch Biochem Biophys. 1998 Sep 15;357(2):179-84. doi: 10.1006/abbi.1998.0812. [Article]

Details5. Calcium-activated potassium channel (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: Yes
Actions: Activator

General Function: Voltage-gated potassium channel activity
Specific Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activati...

Components:

Name	UniProt ID
Calcium-activated potassium channel subunit alpha-1	Q12791
Calcium-activated potassium channel subunit beta-1	Q16558
Calcium-activated potassium channel subunit beta-2	Q9Y691
Calcium-activated potassium channel subunit beta-3	Q9NPA1
Calcium-activated potassium channel subunit beta-4	Q86W47
Intermediate conductance calcium-activated potassium channel protein 4	O15554
Small conductance calcium-activated potassium channel protein 1	Q92952
Small conductance calcium-activated potassium channel protein 2	Q9H2S1
Small conductance calcium-activated potassium channel protein 3	Q9UGI6

References

Hamada Y, Nakaya Y, Hamada S, Kamada M, Aono T: Activation of K+ channels by ritodrine hydrochloride in uterine smooth muscle cells from pregnant women. Eur J Pharmacol. 1994 Dec 15;288(1):45-51. doi: 10.1016/0922-4106(94)90008-6. [Article]

Details6. Myosin light chain kinase, smooth muscle

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.
Specific Function: Actin binding
Gene Name: MYLK
Uniprot ID: Q15746
Uniprot Name: Myosin light chain kinase, smooth muscle
Molecular Weight: 210713.455 Da

References

Sultatos LG: Mechanisms of drugs that affect uterine motility. J Nurse Midwifery. 1997 Jul-Aug;42(4):367-70. doi: 10.1016/s0091-2182(97)60134-2. [Article]

Details7. Sulfotransferase 1C4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
Specific Function: Aryl sulfotransferase activity
Gene Name: SULT1C4
Uniprot ID: O75897
Uniprot Name: Sulfotransferase 1C4
Molecular Weight: 35519.635 Da

References

Hui Y, Liu MC: Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. [Article]

Enzymes

Details1. 6-phosphogluconate dehydrogenase, decarboxylating

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Phosphogluconate dehydrogenase (decarboxylating) activity
Specific Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Gene Name: PGD
Uniprot ID: P52209
Uniprot Name: 6-phosphogluconate dehydrogenase, decarboxylating
Molecular Weight: 53139.56 Da

References

Akkemik E, Budak H, Ciftci M: Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem. 2010 Aug;25(4):476-9. doi: 10.3109/14756360903257900. [Article]
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]

Details2. Sulfotransferase 1A1

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Sulfotransferase activity
Specific Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estroge...
Gene Name: SULT1A1
Uniprot ID: P50225
Uniprot Name: Sulfotransferase 1A1
Molecular Weight: 34165.13 Da

References

Nishimuta H, Tsujimoto M, Ogura K, Hiratsuka A, Ohtani H, Sawada Y: Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Pharm Res. 2005 Aug;22(8):1406-10. doi: 10.1007/s11095-005-5263-y. Epub 2005 Aug 3. [Article]
Hui Y, Liu MC: Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. [Article]

Details3. Sulfotransferase 1A3/1A4

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
Specific Function: Amine sulfotransferase activity
Gene Name: SULT1A3
Uniprot ID: P0DMM9
Uniprot Name: Sulfotransferase 1A3
Molecular Weight: 34195.96 Da

References

Nishimuta H, Tsujimoto M, Ogura K, Hiratsuka A, Ohtani H, Sawada Y: Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Pharm Res. 2005 Aug;22(8):1406-10. doi: 10.1007/s11095-005-5263-y. Epub 2005 Aug 3. [Article]
Hui Y, Liu MC: Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. [Article]

Details4. Sulfotransferase (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Sulfotransferase activity
Specific Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

Components:

Name	UniProt ID
Bile salt sulfotransferase	Q06520
Sulfotransferase 1A1	P50225
Sulfotransferase 1A2	P50226
Sulfotransferase 1A3	P0DMM9
Sulfotransferase 1A4	P0DMN0
Sulfotransferase 1C2	O00338
Sulfotransferase 1C3	Q6IMI6
Sulfotransferase 1C4	O75897
Sulfotransferase 4A1	Q9BR01
Sulfotransferase 6B1	Q6IMI4
Sulfotransferase family cytosolic 1B member 1	O43704

References

Hui Y, Liu MC: Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. [Article]

Details5. Sulfotransferase 1C4

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
Specific Function: Aryl sulfotransferase activity
Gene Name: SULT1C4
Uniprot ID: O75897
Uniprot Name: Sulfotransferase 1C4
Molecular Weight: 35519.635 Da

References

Hui Y, Liu MC: Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. [Article]

Drug created at June 13, 2005 13:24 / Updated at November 03, 2023 23:48

Ritodrine

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Structure for Ritodrine (DB00867)

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