Integrin beta-1

BE0003575ProteinHumansITGB1

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. It is acted on by 5 drugs in DrugBank.

Gene name
ITGB1
UniProtKB entry
P05556Swiss-Prot
Cellular location
Cell membrane
Residues / weight
798 residues · 88,415 Da
Also known as
Fibronectin receptor subunit beta · FNRB · Glycoprotein IIa · GPIIA · MDF2

Resolves to

Protein
UniProtP05556UniProt nameITB1_HUMAN
Gene
HGNCHGNC:6153NCBI Gene3688GenBank31442GeneCardsITGB1
Pharmacology
IUPHAR/GtoPdb2455KEGGhsa:3688
Structure
PDB3G9WPDB3T9KPDB3VI3
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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52GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin beta-1, how selective are they, and which programs against it are still in active trials?

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