Neuronal acetylcholine receptor subunit alpha-6

BE0003587ProteinHumansCHRNA6

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 4 drugs in DrugBank.

Gene name
CHRNA6
UniProtKB entry
Q15825Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
494 residues · 56,898 Da

Resolves to

Protein
UniProtQ15825UniProt nameACHA6_HUMAN
Gene
HGNCHGNC:15963NCBI Gene8973GenBank1458118GeneCardsCHRNA6
Pharmacology
IUPHAR/GtoPdb467KEGGhsa:8973
Structure
PDB8ZRNPDB8ZRP
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
13+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-6, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In