Deoxyguanosine kinase, mitochondrial

BE0003589ProteinHumansDGUOK

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:11687801, PubMed:17073823, PubMed:23043144, PubMed:8692979, PubMed:8706825). It is acted on by 3 drugs in DrugBank.

Gene name
DGUOK
UniProtKB entry
Q16854Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
277 residues · 32,056 Da
Also known as
2.7.1.113 · Deoxyadenosine kinase, mitochondrial · DGK

Resolves to

Protein
UniProtQ16854UniProt nameDGUOK_HUMAN
Gene
HGNCHGNC:2858NCBI Gene1716GenBank1477482GeneCardsDGUOK
Pharmacology
KEGGhsa:1716
Structure
PDB2OCP
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Deoxyguanosine kinase, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In