Gamma-aminobutyric acid receptor subunit delta

BE0003599ProteinHumansGABRD

Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). It is acted on by 4 drugs in DrugBank.

Gene name
GABRD
UniProtKB entry
O14764Swiss-Prot
Cellular location
Cell membrane
Residues / weight
452 residues · 50,708 Da
Also known as
GABA(A) receptor subunit delta · GABAAR subunit delta

Resolves to

Protein
UniProtO14764UniProt nameGBRD_HUMAN
Gene
HGNCHGNC:4084NCBI Gene2563GenBank2388693GeneCardsGABRD
Pharmacology
KEGGhsa:2563
Structure
PDB7QN5PDB7QN6PDB7QN7
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit delta, how selective are they, and which programs against it are still in active trials?

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