Gaboxadol

DB06554InvestigationalSmall molecule

Gaboxadol also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP) is an experimental sleep aid drug developed by Lundbeck and Merck, who reported increased deep sleep without the reinforcing effects of benzodiazepines. Development of... Development of Gaboxadol was stopped in March 2007 after concerns regarding safety and efficacy.

Chemical structure of Gaboxadol
Primary indication
Investigated for use/treatment in sleep disorders and insomnia.Curator reviewed
Formula / weight
C6H8N2O2 · 140.1399 g/mol (avg)
Also known as
THIP
Code names
Lu 02-030 · MK-0928

Resolves to

Compound
UNIIK1M5RVL18SCAS64603-91-4ChEMBLCHEMBL312443ChEBI34373PubChem3448KEGGD04282
Structure
InChIKeyZXRVKCBLGJOCEE-UHFFFAOYSA-NSMILESO=C1NOC2=C1CCNC2
Targets
O14764GABRD
Transporters
Q7Z2H8SLC36A1

What you can answer from here — as of January 29, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1TransporterSubstrate / inhibitor direction, not just membership
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809Drug interactionsStructured to mechanism, not free text
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14Clinical trialsPhase, status and sponsor resolved per trial
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Gaboxadol, and which of those have an active Phase 3 trial?

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