Ribonucleoside-diphosphate reductase subunit M2 B

BE0003613ProteinHumansRRM2B

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. It is acted on by 3 drugs in DrugBank.

Gene name
RRM2B
UniProtKB entry
Q7LG56Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
351 residues · 40,736 Da
Also known as
1.17.4.1 · p53-inducible ribonucleotide reductase small subunit 2-like protein · P53R2 · TP53-inducible ribonucleotide reductase M2 B

Resolves to

Protein
UniProtQ7LG56UniProt nameRIR2B_HUMAN
Gene
HGNCHGNC:17296NCBI Gene50484GenBank7229086GeneCardsRRM2B
Pharmacology
KEGGhsa:50484
Structure
PDB2VUXPDB3HF1PDB4DJN
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribonucleoside-diphosphate reductase subunit M2 B, how selective are they, and which programs against it are still in active trials?

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