Phosphatidylcholine translocator ABCB4

BE0003641ProteinHumansABCB4

Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. It is acted on by 10 drugs in DrugBank.

Gene name
ABCB4
UniProtKB entry
P21439Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,286 residues · 141,522 Da
Also known as
7.6.2.1 · ATP-binding cassette sub-family B member 4 · MDR3 · Multidrug resistance protein 3 · P-glycoprotein 3

Resolves to

Protein
UniProtP21439UniProt nameMDR3_HUMAN
Gene
HGNCHGNC:45NCBI Gene5244GenBank307181GeneCardsABCB4
Pharmacology
KEGGhsa:5244
Structure
PDB6S7PPDB7NIUPDB7NIV
Drugs

What you can answer from here — as of September 03, 2024

10DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylcholine translocator ABCB4, how selective are they, and which programs against it are still in active trials?

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