Oveporexton

DB21680ApprovedSmall molecule

Oveporexton is an oral orexin receptor 2 (OX2R)-selective agonist indicated for narcolepsy type 1 in adults, restoring deficient orexin signaling to promote wakefulness and reduce cataplexy and other REM-sleep-related symptoms. NT1 is caused by the loss of orexin neuropeptide signaling, and oveporexton works by selectively activating OX2R to restore this signaling, promoting wakefulness and reducing cataplexy and other REM-sleep-related symptoms.

Chemical structure of Oveporexton
Mechanism
Curator reviewed
Primary indication
Oveporexton is indicated for the treatment of narcolepsy type 1 (narcolepsy with cataplexy) in adult patients.Curator reviewed · 1 structured indication
Formula / weight
C23H25F5N2O4S · 520.52 g/mol (avg)
Code names
TAK-861

Resolves to

Compound
UNII59MF6P2ATFCAS2460722-04-5ChEMBLCHEMBL6068065ChEBI759983PubChem154617563
Clinical / RWD
ATCG01AE10
Structure
InChIKeyKVMGAIOTUIGROS-AZUAARDMSA-NSMILESCCS(=O)(=O)N[C@@H]1[C@H](CC2=CC=CC(=C2F)C2=CC(F)=CC(F)=C2)N(CC1(F)F)C(=O)C(C)(C)O
Targets
O43614HCRTR2
Transporters
O95342ABCB11O15438ABCC3O15439ABCC4P21439ABCB4

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
4TransportersSubstrate / inhibitor direction, not just membership
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115Drug interactionsStructured to mechanism, not free text
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5Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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3ContraindicationsEach with its own population and attribute set
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1ATC codeIncluding every combination product, plus 11 drug categories
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12+ReferencesStructured and connected to the statements they support
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