High affinity copper uptake protein 1

BE0003649ProteinHumansSLC31A1

Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:11734551, PubMed:16135512, PubMed:17525160, PubMed:19740744, PubMed:20451502, PubMed:20569931, PubMed:23658018) and delivers directly copper(1+) to specific chaperone such as ATOX1,... It is acted on by 6 drugs in DrugBank.

Gene name
SLC31A1
UniProtKB entry
O15431Swiss-Prot
Cellular location
Cell membrane
Residues / weight
190 residues · 21,091 Da
Also known as
Copper transporter 1 · COPT1 · CTR1 · hCTR1 · Solute carrier family 31 member 1

Resolves to

Protein
UniProtO15431UniProt nameCOPT1_HUMAN
Gene
HGNCHGNC:11016NCBI Gene1317GenBank2315987GeneCardsSLC31A1
Pharmacology
KEGGhsa:1317
Structure
PDB2LS2PDB2LS3PDB2LS4
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on High affinity copper uptake protein 1, how selective are they, and which programs against it are still in active trials?

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