POU domain, class 5, transcription factor 1

BE0003665ProteinHumansPOU5F1

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). It is acted on by 3 drugs in DrugBank.

Gene name
POU5F1
UniProtKB entry
Q01860Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
360 residues · 38,570 Da
Also known as
Oct-3 · Oct-4 · OCT3 · OCT4 · Octamer-binding protein 3

Resolves to

Protein
UniProtQ01860UniProt namePO5F1_HUMAN
Gene
HGNCHGNC:9221NCBI Gene5460GenBank35169GeneCardsPOU5F1
Pharmacology
KEGGhsa:5460
Structure
PDB6T90PDB6YOVPDB7U0G
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
17GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on POU domain, class 5, transcription factor 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In