DNA-directed RNA polymerase subunit beta'

BE0003707ProteinEscherichia coli (strain K12)rpoC

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 3 drugs in DrugBank.

Gene name
rpoC
UniProtKB entry
P0A8T7Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
1,407 residues · 155,159 Da
Also known as
2.7.7.6 · RNA polymerase subunit beta' · RNAP subunit beta' · tabB · Transcriptase subunit beta'

Resolves to

Protein
UniProtP0A8T7UniProt nameRPOC_ECOLI
Gene
NCBI Gene948487GenBank42814
Pharmacology
KEGGecj:JW3951
Structure
PDB2AUKPDB2LMCPDB3IYD
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-directed RNA polymerase subunit beta', how selective are they, and which programs against it are still in active trials?

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