Pannexin-1

BE0003719ProteinHumansPANX1

Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). It is acted on by 3 drugs in DrugBank.

Gene name
PANX1
UniProtKB entry
Q96RD7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
426 residues · 48,050 Da
Also known as
MRS1 · PANX1

Resolves to

Protein
UniProtQ96RD7UniProt namePANX1_HUMAN
Gene
HGNCHGNC:8599NCBI Gene24145GenBank3661616GeneCardsPANX1
Pharmacology
IUPHAR/GtoPdb735KEGGhsa:24145
Structure
PDB6LTNPDB6LTOPDB6M02
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pannexin-1, how selective are they, and which programs against it are still in active trials?

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