Phosphatidylinositol 3-kinase catalytic subunit type 3

BE0003729ProteinHumansPIK3C3

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2... It is acted on by 2 drugs in DrugBank.

Gene name
PIK3C3
UniProtKB entry
Q8NEB9Swiss-Prot
Cellular location
Midbody
Residues / weight
887 residues · 101,549 Da
Also known as
2.7.1.137 · hVps34 · Phosphatidylinositol 3-kinase p100 subunit · Phosphoinositide-3-kinase class 3 · PI3-kinase type 3

Resolves to

Protein
UniProtQ8NEB9UniProt namePK3C3_HUMAN
Gene
HGNCHGNC:8974NCBI Gene5289GenBank987948GeneCardsPIK3C3
Pharmacology
IUPHAR/GtoPdb2152KEGGhsa:5289
Structure
PDB11MMPDB11YCPDB13BV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylinositol 3-kinase catalytic subunit type 3, and which indications are they being tested in?

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