Tryptase alpha/beta-1

BE0003736ProteinHumansTPSAB1

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It is acted on by 5 drugs in DrugBank.

Gene name
TPSAB1
UniProtKB entry
Q15661Swiss-Prot
Cellular location
Secreted
Residues / weight
275 residues · 30,515 Da
Also known as
3.4.21.59 · TPS1 · TPS2 · TPSB1 · Tryptase alpha-1

Resolves to

Protein
UniProtQ15661UniProt nameTRYB1_HUMAN
Gene
HGNCHGNC:12019NCBI Gene7177GenBank339981GeneCardsTPSAB1
Pharmacology
IUPHAR/GtoPdb2424KEGGhsa:7177
Structure
PDB1LTOPDB2F9NPDB2F9O
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptase alpha/beta-1, how selective are they, and which programs against it are still in active trials?

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