Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

BE0003739ProteinHumansPIN1

Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). It is acted on by 2 drugs in DrugBank.

Gene name
PIN1
UniProtKB entry
Q13526Swiss-Prot
Cellular location
Nucleus
Residues / weight
163 residues · 18,243 Da
Also known as
5.2.1.8 · Peptidyl-prolyl cis-trans isomerase Pin1 · PPIase Pin1 · Rotamase Pin1

Resolves to

Protein
UniProtQ13526UniProt namePIN1_HUMAN
Gene
HGNCHGNC:8988NCBI Gene5300GenBank1332710GeneCardsPIN1
Pharmacology
IUPHAR/GtoPdb3171KEGGhsa:5300
Structure
PDB1F8APDB1I6CPDB1I8G
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, and which indications are they being tested in?

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