1-deoxypentalenic acid 11-beta-hydroxylase

BE0003748ProteinStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)ptlH

Catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid in the biosynthesis of neopentalenolactone antibiotic. It is acted on by 1 drug in DrugBank.

Gene name
ptlH
UniProtKB entry
Q82IZ1Swiss-Prot
Residues / weight
285 residues · 32,264 Da
Also known as
1.14.11.35 · Neopentalenolactone biosynthesis protein H

Resolves to

Protein
UniProtQ82IZ1UniProt namePTLH_STRAW
Gene
GenBank29603637
Pharmacology
KEGGsma:SAV_2991
Structure
PDB2RDNPDB2RDQPDB2RDR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
6+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on 1-deoxypentalenic acid 11-beta-hydroxylase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In