TGF-beta receptor type-1

BE0003782ProteinHumansTGFBR1

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. It is acted on by 14 drugs in DrugBank.

Gene name
TGFBR1
UniProtKB entry
P36897Swiss-Prot
Cellular location
Cell membrane
Residues / weight
503 residues · 55,959 Da
Also known as
2.7.11.30 · Activin A receptor type II-like protein kinase of 53kD · Activin receptor-like kinase 5 · ALK-5 · ALK5

Resolves to

Protein
UniProtP36897UniProt nameTGFR1_HUMAN
Gene
HGNCHGNC:11772NCBI Gene7046GenBank431035GeneCardsTGFBR1
Pharmacology
IUPHAR/GtoPdb1788KEGGhsa:7046
Structure
PDB1B6CPDB1IASPDB1PY5
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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50GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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83+ReferencesStructured and connected to the statements they support
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Which approved drugs act on TGF-beta receptor type-1, how selective are they, and which programs against it are still in active trials?

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