Itacnosertib

DB21463ExperimentalSmall molecule

Itacnosertib is a small molecule drug. The usage of the INN stem '-sertib' in the name indicates that Itacnosertib is a serine/threonine kinase inhibitor. Itacnosertib has a monoisotopic molecular weight...

Formula / weight: C₂₆H₂₈N₈O · 468.565 g/mol (avg)

Resolves to

Compound

UNII22Z53X5LHFCAS1628870-27-8

Structure

InChIKeyXSQKEVGTZSBVBR-UHFFFAOYSA-NSMILESCOC1=CC(NC2=NC(NC3=CC=CN=C3C3=CC=CC=N3)=CC=N2)=CC=C1N1CCN(C)CC1

Targets

Q04771ACVR1P36897TGFBR1

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Itacnosertib, and which of those have an active Phase 3 trial?

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