Calcium/calmodulin-dependent protein kinase type II subunit beta

BE0003792ProteinHumansCAMK2B

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). It is acted on by 3 drugs in DrugBank.

Gene name
CAMK2B
UniProtKB entry
Q13554Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
666 residues · 72,677 Da
Also known as
2.7.11.17 · CaM kinase II subunit beta · CAM2 · CaMK-II subunit beta · CAMK2

Resolves to

Protein
UniProtQ13554UniProt nameKCC2B_HUMAN
Gene
HGNCHGNC:1461NCBI Gene816GenBank5326757GeneCardsCAMK2B
Pharmacology
IUPHAR/GtoPdb1556KEGGhsa:816
Structure
PDB3BHHPDB7URWPDB7URY
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/calmodulin-dependent protein kinase type II subunit beta, how selective are they, and which programs against it are still in active trials?

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