Prostaglandin reductase 1

BE0003795ProteinHumansPTGR1

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). It is acted on by 5 drugs in DrugBank.

Gene name
PTGR1
UniProtKB entry
Q14914Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
329 residues · 35,870 Da
Also known as
15-oxoprostaglandin 13-reductase · D3T-inducible gene 1 protein · DIG-1 · Dithiolethione-inducible gene 1 protein · Leukotriene B4 12-hydroxydehydrogenase

Resolves to

Protein
UniProtQ14914UniProt namePTGR1_HUMAN
Gene
HGNCHGNC:18429NCBI Gene22949GenBank23271371GeneCardsPTGR1
Pharmacology
KEGGhsa:22949
Structure
PDB1ZSVPDB2Y05PDB9D6W
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostaglandin reductase 1, how selective are they, and which programs against it are still in active trials?

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