LP-184
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- LP-184
- DrugBank Accession Number
- DB18215
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 304.346
Monoisotopic: 304.142307132 - Chemical Formula
- C16H20N2O4
- Synonyms
- (R)-1-HYDROXY-1-((6'-HYDROXY-2',4',6'-TRIMETHYL-7'-OXO-6',7'-DIHYDROSPIRO(CYCLOPROPANE-1,5'-INDEN)-3'-YL)METHYL)UREA
- Hydroxyurea methylacylfulvene
- N-(((6'R)-6',7'-DIHYDRO-6'-HYDROXY-2',4',6'-TRIMETHYL-7'-OXOSPIRO(CYCLOPROPANE-1,5'-(5H)INDEN)-3'-YL)METHYL)-N-HYDROXYUREA
- N-HYDROXY-N-(METHYLACYLFULVENE)UREA
- UREA, N-(((6'R)-6',7'-DIHYDRO-6'-HYDROXY-2',4',6'-TRIMETHYL-7'-OXOSPIRO(CYCLOPROPANE-1,5'-(5H)INDEN)-3'-YL)METHYL)-N-HYDROXY-
- External IDs
- LP 184
- LP-184
- LP184
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- L683VC69K8
- CAS number
- 924835-67-6
- InChI Key
- VWMPVAZEBAKLFR-HNNXBMFYSA-N
- InChI
- InChI=1S/C16H20N2O4/c1-8-6-10-12(11(8)7-18(22)14(17)20)9(2)16(4-5-16)15(3,21)13(10)19/h6,21-22H,4-5,7H2,1-3H3,(H2,17,20)/t15-/m1/s1
- IUPAC Name
- 1-hydroxy-1-{[(6'R)-6'-hydroxy-2',4',6'-trimethyl-7'-oxo-6',7'-dihydrospiro[cyclopropane-1,5'-inden]-3'-yl]methyl}urea
- SMILES
- CC1=C(CN(O)C(N)=O)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 13087731
- ChEMBL
- CHEMBL3781819
- ZINC
- ZINC000034783326
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Recruiting Treatment Advanced Solid Tumors 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 0.047 Chemaxon pKa (Strongest Acidic) 9.14 Chemaxon pKa (Strongest Basic) -3.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 103.86 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 82.45 m3·mol-1 Chemaxon Polarizability 32.04 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 13, 2023 21:22 / Updated at September 17, 2023 04:15