Replicase polyprotein 1ab

BE0003801ProteinSARS-CoVrep

Isoform Replicase polyprotein 1ab Multifunctional protein involved in the transcription and replication of viral RNAs. It is acted on by 11 drugs in DrugBank.

Gene name
rep
UniProtKB entry
P0C6X7Swiss-Prot
Cellular location
Host membrane
Residues / weight
7,073 residues · 790,242 Da
Also known as
ORF1ab polyprotein · pp1ab

Resolves to

Protein
UniProtP0C6X7UniProt nameR1AB_SARS
Gene
NCBI Gene1489680
Pharmacology
KEGGvg:1489680
Structure
PDB1O5SPDB1P76PDB1P9T
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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40GO termsFunction, process and component, as structured annotations
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17Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Replicase polyprotein 1ab, how selective are they, and which programs against it are still in active trials?

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