GS-441524

DB15686InvestigationalSmall molecule

GS-441524 is an experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections. GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivir.

Mechanism: GS-441524 is phosphorylated 3 times to form the active nucleoside triphosphate, which is incorporated into the genome of virions, terminating its replication.
Curator reviewed · 1 reference
Formula / weight: C₁₂H₁₃N₅O₄ · 291.267 g/mol (avg)
Code names: EVO-984 · GS-441524

Resolves to

Compound

UNII1BQK176DT6CAS1191237-69-0ChEMBLCHEMBL2016757ChEBI147281

Clinical / RWD

RxNorm2686165

Structure

InChIKeyBRDWIEOJOWJCLU-LTGWCKQJSA-NSMILESNC1=NC=NN2C1=CC=C2[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N

Targets

P0C6X7repQ05318L

What you can answer from here — as of February 04, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

3Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with GS-441524, and which of those have an active Phase 3 trial?

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