Serine/threonine-protein kinase/endoribonuclease IRE1

BE0003839ProteinHumansERN1

Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:19328063, PubMed:21317875, PubMed:28128204, PubMed:30118681, PubMed:36739529, PubMed:9637683). It is acted on by 3 drugs in DrugBank.

Gene name
ERN1
UniProtKB entry
O75460Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
977 residues · 109,734 Da
Also known as
Endoplasmic reticulum-to-nucleus signaling 1 · hIRE1p · Inositol-requiring protein 1 · IRE1 · Ire1-alpha

Resolves to

Protein
UniProtO75460UniProt nameERN1_HUMAN
Gene
HGNCHGNC:3449NCBI Gene2081GenBank3300094GeneCardsERN1
Pharmacology
IUPHAR/GtoPdb2020KEGGhsa:2081
Structure
PDB2HZ6PDB3P23PDB4U6R
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase/endoribonuclease IRE1, how selective are they, and which programs against it are still in active trials?

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