Toyocamycin

DB13916ExperimentalSmall molecule

4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.

Mechanism: Pharmacologically active on Cyclin-dependent kinase 9, Serine/threonine-protein kinase/endoribonuclease IRE1, and Serine/threonine-protein kinase RIO1
Curator reviewed
Formula / weight: C₁₂H₁₃N₅O₄ · 291.2627 g/mol (avg)
Also known as: Ahygroscopin-B · Cyanotubericidin · Siromycin · Uramycin B · Vengicide
Code names: A-399-Y4 · Antibiotic 1037 · Antibiotic A-399-Y4 · Antibiotic E212 · E-212

Resolves to

Compound

UNIIL7995C4D7FCAS606-58-6ChEMBLCHEMBL99668ChEBI134606

Structure

InChIKeyXOKJUSAYZUAMGJ-WOUKDFQISA-NSMILESNC1=C2C(=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1)C#N

Targets

P50750CDK9O75460ERN1Q9BRS2RIOK1

What you can answer from here — as of July 07, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Toyocamycin, and which of those have an active Phase 3 trial?

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